Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways

Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways

Objective: To investigate the therapeutic efficacy of andrographolide, a plant derived compound, against chikungunya virus (CHIKV) infection. Methods: Using flow cytometry and immunoblotting assay, in vitro viral protein expression was studied in THP-1 cells line. In Balb/c mouse neonates, viral RNA...

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Bibliographic Details
Main Authors: Swati Gupta, Kamla Prasad Mishra, Paban Kumar Dash, Manmohan Parida, Lilly Ganju, Shashi Bala Singh
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Asian Pacific Journal of Tropical Medicine
Subjects:
chikungunya virus
andrographolide
interferon α
protein kinase r
retinoic acid inducible gene-i
tumor necrosis factor α
Online Access:http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=3;spage=214;epage=221;aulast=Gupta

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http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=3;spage=214;epage=221;aulast=Gupta

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