Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors.

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors.

Cytomegalovirus (CMV) elicits long-term T-cell immunity of unparalleled strength, which has allowed the development of highly protective CMV-based vaccine vectors. Counterintuitively, experimental vaccines encoding a single MHC-I restricted epitope offered better immune protection than those express...

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Bibliographic Details
Main Authors: Iryna Dekhtiarenko, Robert B Ratts, Renata Blatnik, Lian N Lee, Sonja Fischer, Lisa Borkner, Jennifer D Oduro, Thomas F Marandu, Stephanie Hoppe, Zsolt Ruzsics, Julia K Sonnemann, Mandana Mansouri, Christine Meyer, Niels A W Lemmermann, Rafaela Holtappels, Ramon Arens, Paul Klenerman, Klaus Früh, Matthias J Reddehase, Angelika B Riemer, Luka Cicin-Sain
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-12-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5158087?pdf=render

Internet

http://europepmc.org/articles/PMC5158087?pdf=render

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