Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages

Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages

IntroductionNon-alcoholic fatty liver disease (NAFLD) has a global prevalence of 25% of the population and is a leading cause of cirrhosis and hepatocellular carcinoma. NAFLD ranges from simple steatosis (non-alcoholic fatty liver) to non-alcoholic steatohepatitis (NASH). Hepatic macrophages, specif...

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Main Authors: Charles Drummer, Fatma Saaoud, Nirag C. Jhala, Ramon Cueto, Yu Sun, Keman Xu, Ying Shao, Yifan Lu, Huimin Shen, Ling Yang, Yan Zhou, Jun Yu, Sheng Wu, Nathaniel W. Snyder, Wenhui Hu, Jia ‘Joe’ Zhuo, Yinghui Zhong, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
non-alcoholic fatty liver disease (NAFLD)
non-alcoholic steatohepatitis (NASH)
caspase-11
inflammation
pyroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1113883/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1113883/full

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