Laminin-coated multifilament entubulation, combined with Schwann cells and glial cell line-derived neurotrophic factor, promotes unidirectional axonal regeneration in a rat model of thoracic spinal cord hemisection

Laminin-coated multifilament entubulation, combined with Schwann cells and glial cell line-derived neurotrophic factor, promotes unidirectional axonal regeneration in a rat model of thoracic spinal cord hemisection

Biomaterial bridging provides physical substrates to guide axonal growth across the lesion. To achieve efficient directional guidance, combinatory strategies using permissive matrix, cells and trophic factors are necessary. In the present study, we evaluated permissive effect of poly (acrylonitrile-...

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Bibliographic Details
Main Authors: Ling-Xiao Deng, Nai-Kui Liu, Ryan Ning Wen, Shuang-Ni Yang, Xuejun Wen, Xiao-Ming Xu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Neural Regeneration Research
Subjects:
axonal regeneration; extracellular molecule; filament density; hemisection; laminin; neurotrophic factor; schwann cell; spinal cord injury; thoracic; transplantation
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=1;spage=186;epage=191;aulast=Deng

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=1;spage=186;epage=191;aulast=Deng

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