Induction of Heparanase-1 Expression by Mutant B-Raf Kinase: Role of GA Binding Protein in Heparanase-1 Promoter Activation

Induction of Heparanase-1 Expression by Mutant B-Raf Kinase: Role of GA Binding Protein in Heparanase-1 Promoter Activation

Heparanase-1 (HPR1), an endoglycosidase that specifically degrades heparan sulfate (HS) proteoglycans, is overexpressed in a variety of malignancies. Our present study sought to determine whether oncogene BRAF and RAS mutations lead to increased HPR1 expression. Reverse transcription-polymerase chai...

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Bibliographic Details
Main Authors: Geetha Rao, Dingxie Liu, Mingzhao Xing, Jordi Tauler, Richard A. Prinz, Xiulong Xu
Format: Article
Language:English
Published: Elsevier 2010-11-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558610800430

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http://www.sciencedirect.com/science/article/pii/S1476558610800430

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