Differential Mechanisms of Cell Death Induced by HDAC Inhibitor SAHA and MDM2 Inhibitor RG7388 in MCF-7 Cells

Differential Mechanisms of Cell Death Induced by HDAC Inhibitor SAHA and MDM2 Inhibitor RG7388 in MCF-7 Cells

Gene expression is often altered by epigenetic modifications that can significantly influence the growth ability and progression of cancers. SAHA (Suberoylanilide hydroxamic acid, also known as Vorinostat), a well-known Histone deacetylase (HDAC) inhibitor, can stop cancer growth and metastatic proc...

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Bibliographic Details
Main Authors: Umamaheswari Natarajan, Thiagarajan Venkatesan, Vijayaraghavan Radhakrishnan, Shila Samuel, Appu Rathinavelu
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cells
Subjects:
SAHA
RG7388
necroptosis
apoptosis
p21
phospho-RIP3
MLKL
MCF-7
Online Access:http://www.mdpi.com/2073-4409/8/1/8

Internet

http://www.mdpi.com/2073-4409/8/1/8

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