Dopamine D2 receptor antagonist counteracts hyperglycemia and insulin resistance in diet-induced obese male mice.

Dopamine D2 receptor antagonist counteracts hyperglycemia and insulin resistance in diet-induced obese male mice.

Obesity leads to insulin resistance (IR) and type 2 diabetes. In humans, low levels of the hormone prolactin (PRL) correlate with IR, adipose tissue (AT) dysfunction, and increased prevalence of T2D. In obese rats, PRL treatment promotes insulin sensitivity and reduces visceral AT adipocyte hypertro...

Full description

Bibliographic Details
Main Authors: Dina I Vázquez-Carrillo, Ana Luisa Ocampo-Ruiz, Arelí Báez-Meza, Gabriela Ramírez-Hernández, Elva Adán-Castro, José Fernando García-Rodrigo, José Luis Dena-Beltrán, Ericka A de Los Ríos, Magdalena Karina Sánchez-Martínez, María Georgina Ortiz, Gonzalo Martínez de la Escalera, Carmen Clapp, Yazmín Macotela
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0301496&type=printable

Internet

https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0301496&type=printable

Similar Items