CSF Secretion Is Not Altered by NKCC1 Nor TRPV4 Antagonism in Healthy Rats

Background: Cerebrospinal fluid (CSF) secretion can be targeted to reduce elevated intracranial pressure (ICP). Sodium-potassium-chloride cotransporter 1 (NKCC1) antagonism is used clinically. However, supporting evidence is limited. The transient receptor potential vanilloid-4 (TRPV4) channel may a...

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Bibliographic Details
Main Authors: Steven W. Bothwell, Daniel Omileke, Adjanie Patabendige, Neil J. Spratt
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Brain Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3425/11/9/1117