Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis.
Sequencing of invasive strains of group A streptococci (GAS) has revealed a diverse array of single nucleotide polymorphisms in the gene encoding the control of virulence regulator (CovR) protein. However, there is limited information regarding the molecular mechanisms by which CovR single amino aci...
Main Authors: | Nicola Horstmann, Pranoti Sahasrabhojane, Bryce Suber, Muthiah Kumaraswami, Randall J Olsen, Anthony Flores, James M Musser, Richard G Brennan, Samuel A Shelburne |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-10-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC3197619?pdf=render |
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