Non-catalytic-Region Mutations Conferring Transition of Class A β-Lactamases Into ESBLs

Non-catalytic-Region Mutations Conferring Transition of Class A β-Lactamases Into ESBLs

Despite class A ESBLs carrying substitutions outside catalytic regions, such as Cys69Tyr or Asn136Asp, have emerged as new clinical threats, the molecular mechanisms underlying their acquired antibiotics-hydrolytic activity remains unclear. We discovered that this non-catalytic-region (NCR) mutation...

Full description

Bibliographic Details
Main Authors: Thinh-Phat Cao, Hyojeong Yi, Immanuel Dhanasingh, Suparna Ghosh, Jin Myung Choi, Kun Ho Lee, Seol Ryu, Heenam Stanley Kim, Sung Haeng Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
extended-spectrum β-lactamase
non-catalytic-region ESBL
ceftazidime
antibiotic resistance
X-ray crystallography
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2020.598998/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2020.598998/full

Similar Items