Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease

Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease

Abstract Background Airway remodeling is a significant contributor to impaired lung function in chronic allergic airway disease. Currently, no therapy exists that is capable of targeting these structural changes and the consequent loss of function. In the context of chronic allergic inflammation, pe...

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Bibliographic Details
Main Authors: Rebecca Bignold, Bushra Shammout, Jessica E. Rowley, Mariaelena Repici, John Simms, Jill R. Johnson
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Respiratory Research
Subjects:
Allergic airway disease
Airway remodeling
Pericyte
CXCR4
LIT-927
Online Access:https://doi.org/10.1186/s12931-022-02108-4

Internet

https://doi.org/10.1186/s12931-022-02108-4

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