Computational Modelling of the Metabolic States Regulated by the Kinase Akt

Computational Modelling of the Metabolic States Regulated by the Kinase Akt

Signal transduction pathways and gene regulation determine a major reorganization of metabolic activities in order to support cell proliferation. Protein Kinase B (PKB), also known as Akt, participates in the PI3K/Akt/mTOR pathway, a master regulator of aerobic glycolysis and cellular biosynthesis,...

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Bibliographic Details
Main Authors: Ettore eMosca, Roberta eAlfieri, Carlo eMaj, Annamaria eBevilacqua, Gianfranco eCanti, Luciano eMilanesi
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-11-01
Series:Frontiers in Physiology
Subjects:
Glycolysis
Metabolism
Cancer
kinetic model
PI3K/AKT/mTOR
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00418/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00418/full

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