Parkin-mediated ubiquitination inhibits BAK apoptotic activity by blocking its canonical hydrophobic groove

Parkin-mediated ubiquitination inhibits BAK apoptotic activity by blocking its canonical hydrophobic groove

Abstract BAK permeabilizes the mitochondrial outer membrane, causing apoptosis. This apoptotic activity of BAK is stimulated by binding prodeath activators within its canonical hydrophobic groove. Parkin, an E3 ubiquitin (Ub) ligase, can ubiquitinate BAK, which inhibits BAK apoptotic activity. Howev...

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Bibliographic Details
Main Authors: Peng Cheng, Yuzhu Hou, Mingxing Bian, Xueru Fang, Yan Liu, Yuanfang Rao, Shuo Cao, Yanjun Liu, Shuai Zhang, Yanke Chen, Xu Dong, Zhu Liu
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05650-z

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https://doi.org/10.1038/s42003-023-05650-z

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