SlgA, encoded by the homolog of the human schizophrenia-associated gene PRODH, acts in clock neurons to regulate Drosophila aggression

SlgA, encoded by the homolog of the human schizophrenia-associated gene PRODH, acts in clock neurons to regulate Drosophila aggression

Mutations in the proline dehydrogenase gene PRODH are linked to behavioral alterations in schizophrenia and as part of DiGeorge and velo-cardio-facial syndromes, but the role of PRODH in their etiology remains unclear. Here, we establish a Drosophila model to study the role of PRODH in behavioral di...

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Bibliographic Details
Main Authors: Liesbeth Zwarts, Veerle Vulsteke, Edgar Buhl, James J. L. Hodge, Patrick Callaerts
Format: Article
Language:English
Published: The Company of Biologists 2017-06-01
Series:Disease Models & Mechanisms
Subjects:
Drosophila
PRODH
Aggression
Clock neuron
Schizophrenia
Online Access:http://dmm.biologists.org/content/10/6/705

Internet

http://dmm.biologists.org/content/10/6/705

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