Optogenetic manipulation of cardiac repolarization gradients using sub-threshold illumination

Optogenetic manipulation of cardiac repolarization gradients using sub-threshold illumination

Introduction: Mechanisms underlying cardiac arrhythmias are typically driven by abnormalities in cardiac conduction and/or heterogeneities in repolarization time (RT) across the heart. While conduction slowing can be caused by either electrophysiological defects or physical blockade in cardiac tissu...

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Bibliographic Details
Main Authors: Gerard A. Marchal, Valentina Biasci, Leslie M. Loew, Annibale Biggeri, Marina Campione, Leonardo Sacconi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Physiology
Subjects:
optogenetics
sub-threshold illumination
optical mapping
electrophysiological modulation
repolarization gradients
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1167524/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1167524/full

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