Mutations in Drosophila tRNA processing factors cause phenotypes similar to Pontocerebellar Hypoplasia

Mutations in Drosophila tRNA processing factors cause phenotypes similar to Pontocerebellar Hypoplasia

Mature transfer (t)RNAs are generated by multiple RNA processing events, which can include the excision of intervening sequences. The tRNA splicing endonuclease (TSEN) complex is responsible for cleaving these intron-containing pre-tRNA transcripts. In humans, TSEN copurifies with CLP1, an RNA kinas...

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Bibliographic Details
Main Authors: Casey A. Schmidt, Lucy Y. Min, Michelle H. McVay, Joseph D. Giusto, John C. Brown, Harmony R. Salzler, A. Gregory Matera
Format: Article
Language:English
Published: The Company of Biologists 2022-03-01
Series:Biology Open
Subjects:
rna processing
animal models of human disease
neurodegeneration
trna splicing
Online Access:http://bio.biologists.org/content/11/3/bio058928

Internet

http://bio.biologists.org/content/11/3/bio058928

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