Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules

Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules

4-Hydrophenylpyruvate dioxygenase (HPPD), a key enzyme involved in tyrosine catabolism, has long been considered a promising target for herbicides and drugs. Several types of HPPD inhibitors have been developed as high-potency drugs or herbicides. Understanding the structural basis of the binding of...

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Bibliographic Details
Main Authors: Jin Dong, Jiangqing Dong, Xin-He Yu, Yao-Chao Yan, Jia-Xu Nan, Bo He, Bao-Qin Ye, Wen-Chao Yang, Hong-Yan Lin, Guang-Fu Yang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-12-01
Series:Advanced Agrochem
Subjects:
4-Hydrophenylpyruvate dioxygenase (HPPD)
Crystal structures
Inhibitors
Binding mode
Herbicide
Online Access:http://www.sciencedirect.com/science/article/pii/S2773237122000211

Internet

http://www.sciencedirect.com/science/article/pii/S2773237122000211

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