Paclitaxel Potentiates the Anticancer Effect of Cetuximab by Enhancing Antibody-Dependent Cellular Cytotoxicity on Oral Squamous Cell Carcinoma Cells In Vitro

Paclitaxel Potentiates the Anticancer Effect of Cetuximab by Enhancing Antibody-Dependent Cellular Cytotoxicity on Oral Squamous Cell Carcinoma Cells In Vitro

Administration of cetuximab (C-mab) in combination with paclitaxel (PTX) has been used for patients with head and neck squamous cell carcinoma (SCC) clinically. In this study, we attempted to clarify the molecular mechanisms of the enhancing anticancer effect of C-mab combined with PTX on oral SCC c...

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Bibliographic Details
Main Authors: Yuta Sawatani, Yuske Komiyama, Koh-ichi Nakashiro, Daisuke Uchida, Chonji Fukumoto, Michiko Shimura, Tomonori Hasegawa, Ryouta Kamimura, Masayo Hitomi-Koide, Toshiki Hyodo, Hitoshi Kawamata
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
antibody-dependent cellular cytotoxicity (ADCC)
cetuximab
paclitaxel
synergistic effects
oral squamous cell carcinoma (OSCC)
epidermal growth factor receptor (EGFR)
Online Access:https://www.mdpi.com/1422-0067/21/17/6292

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https://www.mdpi.com/1422-0067/21/17/6292

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