Loss-of-function variants in ITSN1 confer high risk of Parkinson’s disease

Loss-of-function variants in ITSN1 confer high risk of Parkinson’s disease

Abstract Parkinson’s disease (PD) is a debilitating neurodegenerative disorder and its rising global incidence highlights the need for the identification of modifiable risk factors. In a gene-based burden test of rare variants (8647 PD cases and 777,693 controls) we discovered a novel association be...

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Bibliographic Details
Main Authors: Astros Th. Skuladottir, Vinicius Tragante, Gardar Sveinbjornsson, Hannes Helgason, Arni Sturluson, Anna Bjornsdottir, Palmi Jonsson, Vala Palmadottir, Olafur A. Sveinsson, Brynjar O. Jensson, Sigurjon A. Gudjonsson, Erna V. Ivarsdottir, Rosa S. Gisladottir, Arni F. Gunnarsson, G. Bragi Walters, Gudrun A. Jonsdottir, Thorgeir E. Thorgeirsson, Gyda Bjornsdottir, Hilma Holm, Daniel F. Gudbjartsson, Patrick Sulem, Hreinn Stefansson, Kari Stefansson
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-024-00752-9

Internet

https://doi.org/10.1038/s41531-024-00752-9

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