Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements
Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition, yet their sensitivity and specificity are still poorly defined. Here, authors report a FRET-based sensor that informs directly on the magnitude and kinetics of TCR-impose...
| Auteurs principaux: | , , , , , , , |
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| Format: | Article |
| Langue: | English |
| Publié: |
Nature Portfolio
2021-05-01
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| Collection: | Nature Communications |
| Accès en ligne: | https://doi.org/10.1038/s41467-021-22775-z |