Synthesis and Optimization of Mesoporous Silica Nanoparticles for Ruthenium Polypyridyl Drug Delivery

The ruthenium polypyridyl complex [Ru(dppz)<sub>2</sub>PIP]<sup>2+</sup> (dppz: dipyridophenazine, PIP: (2-(phenyl)-imidazo[4,5-f ][1,10]phenanthroline), or Ru-PIP, is a potential anticancer drug that acts by inhibiting DNA replication. Due to the poor dissolution of Ru-PIP i...

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Bibliographic Details
Main Authors: Siti Norain Harun, Haslina Ahmad, Hong Ngee Lim, Suet Lin Chia, Martin R. Gill
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceutics
Subjects:
Online Access:https://www.mdpi.com/1999-4923/13/2/150