Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy

Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy

Alzheimer's disease (AD), characterized by the accumulation of protein aggregates including phosphorylated Tau aggregates, is the most common neurodegenerative disorder with limited therapeutic agents. Autophagy plays a critical role in the degradation of phosphorylated Tau aggregates, and tran...

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Bibliographic Details
Main Authors: Chuanbin Yang, Chengfu Su, Ashok Iyaswamy, Senthil Kumar Krishnamoorthi, Zhou Zhu, Sichang Yang, Benjamin Chunkit Tong, Jia Liu, Sravan G. Sreenivasmurthy, Xinjie Guan, Yuxuan Kan, Aston Jiaxi Wu, Alexis Shiying Huang, Jieqiong Tan, Kingho Cheung, Juxian Song, Min Li
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
TFEB
Autophagy
Lysosome biogenesis
Alzheimer's disease (AD)
Tau
Celastrol
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522000478

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http://www.sciencedirect.com/science/article/pii/S2211383522000478

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