Anthocyanins from purple corn ameliorated obesity in high fat diet-induced obese mice through activating hepatic AMPK
Anthocyanins are the predominant bioactive compounds in purple corn. Various studies suggested that anthocyanins from purple corn (APM) not only provide color but also provide potential health-promoting properties. However, there is no research addressing the antiobesity effects of APM via hepatic A...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464621002310 |
| _version_ | 1818678120210759680 |
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| author | Hongyan Xu Meihong Liu Huimin Liu Bailing Zhao Mingzhu Zheng Jingsheng Liu |
| author_facet | Hongyan Xu Meihong Liu Huimin Liu Bailing Zhao Mingzhu Zheng Jingsheng Liu |
| author_sort | Hongyan Xu |
| collection | DOAJ |
| description | Anthocyanins are the predominant bioactive compounds in purple corn. Various studies suggested that anthocyanins from purple corn (APM) not only provide color but also provide potential health-promoting properties. However, there is no research addressing the antiobesity effects of APM via hepatic AMP-activated protein kinase (AMPK) pathway. We find that APM administration (400 mg/kg) significantly decreased body weight gain, epididymal fat mass, total cholesterol and total triglyceride levels in HFD mice. Quantitative PCR analysis revealed that APM down-regulated the expression of PPARγ, C/EBPα and SREBP-1c, concurrently up-regulated the expression of PPARα, PGC1α, PRDM16, and FGF21. Besides, Western blot analysis confirmed that APM promoted hepatic AMPK activity, then blocked ACC activity, which was the key enzyme in lipid synthase. These findings suggested that APM-induced activation of hepatic AMPK leads to a decrease in fatty acid synthase and an increase in fatty acid oxidation. Therefore, we inferred that APM has the potential for obesity prevention. |
| first_indexed | 2024-12-17T09:10:13Z |
| format | Article |
| id | doaj.art-9ab20dcce2a44ea480ba2e151d08b0fe |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T09:10:13Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-9ab20dcce2a44ea480ba2e151d08b0fe2022-12-21T21:55:15ZengElsevierJournal of Functional Foods1756-46462021-09-0184104582Anthocyanins from purple corn ameliorated obesity in high fat diet-induced obese mice through activating hepatic AMPKHongyan Xu0Meihong Liu1Huimin Liu2Bailing Zhao3Mingzhu Zheng4Jingsheng Liu5College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China; National Engineering Laboratory for Wheat and Corn Deep Processing, Jilin Agricultural University, Changchun, Jilin 130118, China; Department of Food Science and Engineering, College of Agriculture, Yanbian University, Yanji, Jilin 133000, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China; National Engineering Laboratory for Wheat and Corn Deep Processing, Jilin Agricultural University, Changchun, Jilin 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China; National Engineering Laboratory for Wheat and Corn Deep Processing, Jilin Agricultural University, Changchun, Jilin 130118, China; Corresponding authors at: College of Food Science and Engineering, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, China.College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China; National Engineering Laboratory for Wheat and Corn Deep Processing, Jilin Agricultural University, Changchun, Jilin 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China; National Engineering Laboratory for Wheat and Corn Deep Processing, Jilin Agricultural University, Changchun, Jilin 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China; National Engineering Laboratory for Wheat and Corn Deep Processing, Jilin Agricultural University, Changchun, Jilin 130118, China; Corresponding authors at: College of Food Science and Engineering, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, China.Anthocyanins are the predominant bioactive compounds in purple corn. Various studies suggested that anthocyanins from purple corn (APM) not only provide color but also provide potential health-promoting properties. However, there is no research addressing the antiobesity effects of APM via hepatic AMP-activated protein kinase (AMPK) pathway. We find that APM administration (400 mg/kg) significantly decreased body weight gain, epididymal fat mass, total cholesterol and total triglyceride levels in HFD mice. Quantitative PCR analysis revealed that APM down-regulated the expression of PPARγ, C/EBPα and SREBP-1c, concurrently up-regulated the expression of PPARα, PGC1α, PRDM16, and FGF21. Besides, Western blot analysis confirmed that APM promoted hepatic AMPK activity, then blocked ACC activity, which was the key enzyme in lipid synthase. These findings suggested that APM-induced activation of hepatic AMPK leads to a decrease in fatty acid synthase and an increase in fatty acid oxidation. Therefore, we inferred that APM has the potential for obesity prevention.http://www.sciencedirect.com/science/article/pii/S1756464621002310Purple cornAnthocyaninsAMPKAdipogenesisMitochondrialObesity |
| spellingShingle | Hongyan Xu Meihong Liu Huimin Liu Bailing Zhao Mingzhu Zheng Jingsheng Liu Anthocyanins from purple corn ameliorated obesity in high fat diet-induced obese mice through activating hepatic AMPK Journal of Functional Foods Purple corn Anthocyanins AMPK Adipogenesis Mitochondrial Obesity |
| title | Anthocyanins from purple corn ameliorated obesity in high fat diet-induced obese mice through activating hepatic AMPK |
| title_full | Anthocyanins from purple corn ameliorated obesity in high fat diet-induced obese mice through activating hepatic AMPK |
| title_fullStr | Anthocyanins from purple corn ameliorated obesity in high fat diet-induced obese mice through activating hepatic AMPK |
| title_full_unstemmed | Anthocyanins from purple corn ameliorated obesity in high fat diet-induced obese mice through activating hepatic AMPK |
| title_short | Anthocyanins from purple corn ameliorated obesity in high fat diet-induced obese mice through activating hepatic AMPK |
| title_sort | anthocyanins from purple corn ameliorated obesity in high fat diet induced obese mice through activating hepatic ampk |
| topic | Purple corn Anthocyanins AMPK Adipogenesis Mitochondrial Obesity |
| url | http://www.sciencedirect.com/science/article/pii/S1756464621002310 |
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