Receptors with low affinity for neurosteroids and GABA contribute to tonic inhibition of granule cells in epileptic animals

Receptors with low affinity for neurosteroids and GABA contribute to tonic inhibition of granule cells in epileptic animals

Neurosteroid sensitivity of GABAA receptor mediated inhibition of the hippocampal dentate granule cells (DGCs) is reduced in animal models of temporal lobe epilepsy. However, the properties and subunit composition of GABAA receptors mediating tonic inhibition in DGCs of epileptic animals have not be...

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Bibliographic Details
Main Authors: Karthik Rajasekaran, Suchitra Joshi, Chengsan Sun, Zakaria Mtchedlishvilli, Jaideep Kapur
Format: Article
Language:English
Published: Elsevier 2010-11-01
Series:Neurobiology of Disease
Subjects:
Temporal lobe epilepsy
Dentate granule cells
GABA-A receptor
Tonic inhibition
Neurosteroids
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611000241X

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http://www.sciencedirect.com/science/article/pii/S096999611000241X

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