Antioxidants restore store‐operated Ca2+ entry in patient‐iPSC‐derived myotubes with tubular aggregate myopathy‐associated Ile484ArgfsX21 STIM1 mutation via upregulation of binding immunoglobulin protein

Antioxidants restore store‐operated Ca2+ entry in patient‐iPSC‐derived myotubes with tubular aggregate myopathy‐associated Ile484ArgfsX21 STIM1 mutation via upregulation of binding immunoglobulin protein

Abstract Store‐operated Ca2+ entry (SOCE) is indispensable for intracellular Ca2+ homeostasis in skeletal muscle, and constitutive activation of SOCE causes tubular aggregate myopathy (TAM). To understand the pathogenesis of TAM, we induced pluripotent stem cells (iPSCs) from a TAM patient with a ra...

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Bibliographic Details
Main Authors: Fusako Sakai‐Takemura, Fumiaki Saito, Ken'ichiro Nogami, Yusuke Maruyama, Ahmed Elhussieny, Kiichiro Matsumura, Shin'ichi Takeda, Yoshitsugu Aoki, Yuko Miyagoe‐Suzuki
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:FASEB BioAdvances
Subjects:
antioxidants
binding immunoglobulin protein
calcium
calcium release‐activated calcium channel protein 1 (ORAI1)
induced pluripotent stem cells
skeletal muscle
Online Access:https://doi.org/10.1096/fba.2023-00069

Internet

https://doi.org/10.1096/fba.2023-00069

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