MSC-derived small extracellular vesicles overexpressing miR-20a promoted the osteointegration of porous titanium alloy by enhancing osteogenesis via targeting BAMBI

MSC-derived small extracellular vesicles overexpressing miR-20a promoted the osteointegration of porous titanium alloy by enhancing osteogenesis via targeting BAMBI

Abstract Background Patients with osteoporosis have a high risk of implant loosening due to poor osteointegration, possibly leading to implant failure, implant revision, and refracture. RNA interference therapy is an emerging epigenetic treatment, and we found that miR-20a could enhance osteogenesis...

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Bibliographic Details
Main Authors: Wei Liu, Jinghuan Huang, Feng Chen, Dong Xie, Longqing Wang, Cheng Ye, Qi Zhu, Xiang Li, Xiaolin Li, Lili Yang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Stem Cell Research & Therapy
Subjects:
Mir-20a
Small extracellular vesicles
Overexpressing
Osteogenesis
Osteointegration
Synergetic effect
Online Access:https://doi.org/10.1186/s13287-021-02303-y

Internet

https://doi.org/10.1186/s13287-021-02303-y

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