Methylpiperidinopyrazole Attenuates Estrogen-Induced Mitochondrial Energy Production and Subsequent Osteoblast Maturation via an Estrogen Receptor Alpha-Dependent Mechanism

Methylpiperidinopyrazole Attenuates Estrogen-Induced Mitochondrial Energy Production and Subsequent Osteoblast Maturation via an Estrogen Receptor Alpha-Dependent Mechanism

An estrogen deficiency is the main cause of osteoporosis in postmenopausal women. In bone remodeling, estrogen receptors (ERs) can mediate estrogen-transducing signals. Methylpiperidinopyrazole (MPP) is a highly specific antagonist of ER-alpha (ERα). This study was designed to evaluate the effects o...

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Bibliographic Details
Main Authors: Poh-Shiow Yeh, Jui-Tai Chen, Yih-Giun Cherng, Shun-Tai Yang, Yu-Ting Tai, Ruei-Ming Chen
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Molecules
Subjects:
estrogen
methylpiperidinopyrazole
osteoblast maturation
energy production
osteogenesis
Online Access:https://www.mdpi.com/1420-3049/25/12/2876

Internet

https://www.mdpi.com/1420-3049/25/12/2876

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