A Rat Model of Clinically Relevant Extracorporeal Circulation Develops Early Organ Dysfunctions

A Rat Model of Clinically Relevant Extracorporeal Circulation Develops Early Organ Dysfunctions

In clinical practice, extracorporeal circulation (ECC) is associated with coagulopathy and inflammation, eventually leading to organ injuries without preventive systemic pharmacological treatment. Relevant models are needed to reproduce the pathophysiology observed in humans and preclinical tests. R...

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Bibliographic Details
Main Authors: Antoine Persello, Fouzia Souab, Thomas Dupas, Virginie Aillerie, Edith Bigot, Manon Denis, Angélique Erraud, Thomas Pelé, Angélique Blangy-Letheule, Pierre Miniou, Philippe Guedat, Michel De Waard, Emmanuelle Abgueguen, Bertrand Rozec, Benjamin Lauzier
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
extracorporeal circulation
rat model
cardiac surgery
patients cohort
transcriptomics
Online Access:https://www.mdpi.com/1422-0067/24/8/7338

Internet

https://www.mdpi.com/1422-0067/24/8/7338

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