Spontaneous episodic inflammation in the intestines of mice lacking HNF4A is driven by microbiota and associated with early life microbiota alterations

Spontaneous episodic inflammation in the intestines of mice lacking HNF4A is driven by microbiota and associated with early life microbiota alterations

ABSTRACT The inflammatory bowel diseases (IBD) occur in genetically susceptible individuals who mount inappropriate immune responses to their microbiota leading to chronic intestinal inflammation. Whereas IBD clinical presentation is well described, how interactions between microbiota and host genot...

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Bibliographic Details
Main Authors: Cecelia Kelly, Jayanth Jawahar, Lauren Davey, Jeffrey I. Everitt, Joseph A. Galanko, Chelsea Anderson, Jonathan E. Avendano, Jessica R. McCann, R. Balfour Sartor, Raphael H. Valdivia, John F. Rawls
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
inflammatory bowel disease
gut microbiome
gut inflammation
HNF4A
NR2A1
longitudinal analysis
Online Access:https://journals.asm.org/doi/10.1128/mbio.01504-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01504-23

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