Advancing Precision Oncology in Hereditary Paraganglioma-Pheochromocytoma Syndromes: Integrated Interpretation and Data Sharing of the Germline and Tumor Genomes

Advancing Precision Oncology in Hereditary Paraganglioma-Pheochromocytoma Syndromes: Integrated Interpretation and Data Sharing of the Germline and Tumor Genomes

Standard methods of variant assessment in hereditary cancer susceptibility genes are limited by the lack of availability of key supporting evidence. In cancer, information derived from tumors can serve as a useful source in delineating the tumor behavior and the role of germline variants in tumor pr...

Full description

Bibliographic Details
Main Authors: Huma Q. Rana, Diane R. Koeller, McKenzie Walker, Busra Unal, Alison Schwartz Levine, Anu Chittenden, Raymond A. Isidro, Connor P. Hayes, Monica D. Manam, Ryan M. Buehler, Danielle K. Manning, Justine A. Barletta, Jason L. Hornick, Judy E. Garber, Arezou A. Ghazani, INT<sup>2</sup>GRATE Oncology Consortium
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cancers
Subjects:
INT<sup>2</sup>GRATE Oncology Consortium
somatic and germline integration
INT<sup>2</sup>GRATE
tumor signature profile
germline VUS
hereditary paraganglioma–pheochromocytoma syndromes (HPPGLs)
Online Access:https://www.mdpi.com/2072-6694/16/5/947

Internet

https://www.mdpi.com/2072-6694/16/5/947

Similar Items