The Mitochondrial Antioxidant Sirtuin3 Cooperates with Lipid Metabolism to Safeguard Neurogenesis in Aging and Depression

The Mitochondrial Antioxidant Sirtuin3 Cooperates with Lipid Metabolism to Safeguard Neurogenesis in Aging and Depression

Neural stem cells (NSCs), crucial for memory in the adult brain, are also pivotal to buffer depressive behavior. However, the mechanisms underlying the boost in NSC activity throughout life are still largely undiscovered. Here, we aimed to explore the role of deacetylase Sirtuin 3 (SIRT3), a central...

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Bibliographic Details
Main Authors: Sónia Sá Santos, João B. Moreira, Márcia Costa, Rui S. Rodrigues, Ana M. Sebastião, Sara Xapelli, Susana Solá
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
aging
depression
lipid metabolism
mitochondria
neural stem cells
SIRT3
Online Access:https://www.mdpi.com/2073-4409/11/1/90

Internet

https://www.mdpi.com/2073-4409/11/1/90

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