The Mitochondrial Antioxidant Sirtuin3 Cooperates with Lipid Metabolism to Safeguard Neurogenesis in Aging and Depression
Neural stem cells (NSCs), crucial for memory in the adult brain, are also pivotal to buffer depressive behavior. However, the mechanisms underlying the boost in NSC activity throughout life are still largely undiscovered. Here, we aimed to explore the role of deacetylase Sirtuin 3 (SIRT3), a central...
Main Authors: | Sónia Sá Santos, João B. Moreira, Márcia Costa, Rui S. Rodrigues, Ana M. Sebastião, Sara Xapelli, Susana Solá |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-12-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/11/1/90 |
Similar Items
-
Mitochondrial Sirtuins in Reproduction
by: Giovanna Di Emidio, et al.
Published: (2021-06-01) -
SIRT7 and hepatic lipid metabolism
by: Bor Luen eTang
Published: (2015-01-01) -
Sirtuins and redox signaling interplay in neurogenesis, neurodegenerative diseases, and neural cell reprogramming
by: Elisabetta Mormone, et al.
Published: (2023-02-01) -
Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death
by: Yue Sun, et al.
Published: (2022-07-01) -
Mitochondrial Sirtuins in Chronic Degenerative Diseases: New Metabolic Targets in Colorectal Cancer
by: Antonino Colloca, et al.
Published: (2022-03-01)