Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis

Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis

Neovascular eye diseases including retinopathy of prematurity, diabetic retinopathy and age-related-macular-degeneration are major causes of blindness. Fenofibrate treatment in type 2 diabetes patients reduces progression of diabetic retinopathy independent of its peroxisome proliferator-activated r...

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Bibliographic Details
Main Authors: Yan Gong, Zhuo Shao, Zhongjie Fu, Matthew L. Edin, Ye Sun, Raffael G. Liegl, Zhongxiao Wang, Chi-Hsiu Liu, Samuel B. Burnim, Steven S. Meng, Fred B. Lih, John Paul SanGiovanni, Darryl C. Zeldin, Ann Hellström, Lois E.H. Smith
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:EBioMedicine
Subjects:
Fenofibrate
Choroidal neovascularization
Retinopathy
Retinal neovascularization
Cytochrome P450 epoxygenase 2C
Omega-3 long-chain polyunsaturated fatty acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416304480

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http://www.sciencedirect.com/science/article/pii/S2352396416304480

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