SOSSB1 and SOSSB2 mutually regulate protein stability through competitive binding of SOSSA

Abstract Human single-stranded DNA-binding protein homologs hSSB1 (SOSSB1) and hSSB2 (SOSSB2) make a vital impact on maintaining genome stability as the B subunits of the sensor of single-stranded DNA complex (SOSS). However, whether and how SOSSB1 and SOSSB2 modulate mutual expression is unclear. T...

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Bibliographic Details
Main Authors: Qi Zhang, Rongjiao Hao, Hongxia Chen, Gangqiao Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01619-3