A yellow fever virus NS4B inhibitor not only suppresses viral replication, but also enhances the virus activation of RIG-I-like receptor-mediated innate immune response.

A yellow fever virus NS4B inhibitor not only suppresses viral replication, but also enhances the virus activation of RIG-I-like receptor-mediated innate immune response.

Flavivirus infection of cells induces massive rearrangements of the endoplasmic reticulum (ER) membrane to form viral replication organelles (ROs) which segregates viral RNA replication intermediates from the cytoplasmic RNA sensors. Among other viral nonstructural (NS) proteins, available evidence...

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Bibliographic Details
Main Authors: Zhao Gao, Xuexiang Zhang, Lin Zhang, Shuo Wu, Julia Ma, Fuxuan Wang, Yan Zhou, Xinghong Dai, Esther Bullitt, Yanming Du, Ju-Tao Guo, Jinhong Chang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010271

Internet

https://doi.org/10.1371/journal.ppat.1010271

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