Solubility measurement and modeling of hydroxychloroquine sulfate (antimalarial medication) in supercritical carbon dioxide

Abstract A supercritical fluid, such as supercritical carbon dioxide (scCO2) is increasingly used for the micronization of pharmaceuticals in the recent past. The role of scCO2 as a green solvent in supercritical fluid (SCF) process is decided by the solubility information of the pharmaceutical comp...

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Bibliographic Details
Main Authors: Gholamhossein Sodeifian, Chandrasekhar Garlapati, Maryam Arbab Nooshabadi, Fariba Razmimanesh, Amirmuhammad Tabibzadeh
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-34900-7