Probes for the heterogeneity of muscimol binding sites in rat brain

Probes for the heterogeneity of muscimol binding sites in rat brain

Introduction: The plant-based alkaloid muscimol is a potent agonist of inhibitory GABAA-neurotransmitter receptors. GABAA receptors are a heterogeneous family of pentameric complexes, with 5 out of 19 subunits assembling around the central anion pore. Muscimol is considered to bind to all receptor s...

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Bibliographic Details
Main Authors: Veronika Müller, Margot Ernst, Aygul Baykuchkarova, Filip Koniuszewski, Konstantina Bampali, Thomas Seidel, Petra Scholze
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
GABAA-receptor subtypes
radioligand displacement analysis
muscimol binding
rat brain
binding site heterogeneity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1368527/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1368527/full

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