Conductance Changes of Na<sup>+</sup> Channels during the Late Na<sup>+</sup> Current Flowing under Action Potential Voltage Clamp Conditions in Canine, Rabbit, and Guinea Pig Ventricular Myocytes

Conductance Changes of Na<sup>+</sup> Channels during the Late Na<sup>+</sup> Current Flowing under Action Potential Voltage Clamp Conditions in Canine, Rabbit, and Guinea Pig Ventricular Myocytes

Late sodium current (I<sub>Na,late</sub>) is an important inward current contributing to the plateau phase of the action potential (AP) in the mammalian heart. Although I<sub>Na,late</sub> is considered as a possible target for antiarrhythmic agents, several aspects of this c...

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Bibliographic Details
Main Authors: Balázs Horváth, Zsigmond M. Kovács, Csaba Dienes, József Óvári, Norbert Szentandrássy, János Magyar, Tamás Bányász, András Varró, Péter P. Nánási
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Pharmaceuticals
Subjects:
late Na<sup>+</sup> current
ventricular repolarization
action potential voltage clamp
ventricular myocytes
mammalian heart
Online Access:https://www.mdpi.com/1424-8247/16/4/560

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https://www.mdpi.com/1424-8247/16/4/560

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