Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR

Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR

IRE1 and PERK, both important mediators of the unfold protein response pathway, are differentially regulated during plasma cell differentiation. Here the authors show that an ufmylation target, Ufbp1, suppresses PERK to stimulate plasma cell development and is induced by the IRE1/XBP1 pathway to pro...

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Bibliographic Details
Main Authors: Huabin Zhu, Brinda Bhatt, Sathish Sivaprakasam, Yafei Cai, Siyang Liu, Sai Karthik Kodeboyina, Nikhil Patel, Natasha M. Savage, Ashok Sharma, Randal J. Kaufman, Honglin Li, Nagendra Singh
Format: Article
Language:English
Published: Nature Portfolio 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08908-5

Internet

https://doi.org/10.1038/s41467-019-08908-5

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