The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors

The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors

NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Once activated, NLRP3 initiates the inflammasome assembly together wit...

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Bibliographic Details
Main Authors: Xiaoyan Zhan, Qiang Li, Guang Xu, Xiaohe Xiao, Zhaofang Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
pattern recognition receptor
NLRP3
inflammasome
inflammatory diseases
pharmacological inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1109938/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1109938/full

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