Gut microbiota-derived indole 3-propionic acid partially activates aryl hydrocarbon receptor to promote macrophage phagocytosis and attenuate septic injury

Gut microbiota-derived indole 3-propionic acid partially activates aryl hydrocarbon receptor to promote macrophage phagocytosis and attenuate septic injury

Sepsis is associated with a high risk of death, and the crosstalk between gut microbiota and sepsis is gradually revealed. Indole 3-propionic acid (IPA) is a gut microbiota-derived metabolite that exerts immune regulation and organ protective effects. However, the role of IPA in sepsis is not clear....

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Bibliographic Details
Main Authors: Zhi-Bin Huang, Zhen Hu, Chen-Xin Lu, Si-Dan Luo, Yu Chen, Zhi-Peng Zhou, Jing-Juan Hu, Fang-Ling Zhang, Fan Deng, Ke-Xuan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
gut microbiota
macrophage
phagocytosis
sepsis
infection
indole 3-propionic acid
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.1015386/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2022.1015386/full

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