Preparative Scale Production of Recombinant Human Transthyretin for Biophysical Studies of Protein-Ligand and Protein-Protein Interactions

Preparative Scale Production of Recombinant Human Transthyretin for Biophysical Studies of Protein-Ligand and Protein-Protein Interactions

Human transthyretin (hTTR), a serum protein with a main role in transporting thyroid hormones and retinol through binding to the retinol-binding protein, is an amyloidogenic protein involved in familial amyloidotic polyneuropathy (FAP), familial amyloidotic cardiomyopathy, and central nervous system...

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Bibliographic Details
Main Authors: Ellen Y. Cotrina, Marta Vilà, Joan Nieto, Gemma Arsequell, Antoni Planas
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
transthyretin
recombinant expression
fed-batch culture
protein yield
protein-ligand interactions
protein-protein interactions
Online Access:https://www.mdpi.com/1422-0067/21/24/9640

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https://www.mdpi.com/1422-0067/21/24/9640

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