Cerebrospinal Fluid of Patients With Alzheimer’s Disease Contains Increased Percentages of Synaptophysin-Bearing Microvesicles

Cerebrospinal Fluid of Patients With Alzheimer’s Disease Contains Increased Percentages of Synaptophysin-Bearing Microvesicles

IntroductionIn Alzheimer’s disease, the severity of symptoms is linked to a loss of synaptic density and the spread of pathologically hyperphosphorylated tau. The established cerebrospinal fluid markers Aβ, tau and phospho-tau reflect the histopathological hallmarks of Alzheimer’s disease but do not...

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Bibliographic Details
Main Authors: Janine Utz, Judith Berner, Luis Enrique Muñoz, Timo Jan Oberstein, Johannes Kornhuber, Martin Herrmann, Juan Manuel Maler, Philipp Spitzer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
synaptophysin
microvesicle
biomarker
synaptic loss
extracellular vesicles
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.682115/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.682115/full

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