Cerebrospinal Fluid of Patients With Alzheimer’s Disease Contains Increased Percentages of Synaptophysin-Bearing Microvesicles

Cerebrospinal Fluid of Patients With Alzheimer’s Disease Contains Increased Percentages of Synaptophysin-Bearing Microvesicles

IntroductionIn Alzheimer’s disease, the severity of symptoms is linked to a loss of synaptic density and the spread of pathologically hyperphosphorylated tau. The established cerebrospinal fluid markers Aβ, tau and phospho-tau reflect the histopathological hallmarks of Alzheimer’s disease but do not...

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Bibliographic Details
Main Authors:	Janine Utz, Judith Berner, Luis Enrique Muñoz, Timo Jan Oberstein, Johannes Kornhuber, Martin Herrmann, Juan Manuel Maler, Philipp Spitzer
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-07-01
Series:	Frontiers in Aging Neuroscience
Subjects:	Alzheimer’s disease synaptophysin microvesicle biomarker synaptic loss extracellular vesicles
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2021.682115/full

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