Paradoxical Acceleration of Dithiothreitol-Induced Aggregation of Insulin in the Presence of a Chaperone

The kinetics of dithiothreitol (DTT)-induced aggregation of human recombinant insulin and the effect of α-crystallin, a representative of the family of small heat shock proteins, on the aggregation process have been studied using dynamic light scattering technique. Analysis of the distribution of th...

Full description

Bibliographic Details
Main Authors: Boris Kurganov, Konstantin Muranov, Natalya Artemova, Bella Gurvits, Zoya Bumagina
Format: Article
Language:English
Published: MDPI AG 2010-11-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:http://www.mdpi.com/1422-0067/11/11/4556/