Ex Vivo Chromosomal Radiosensitivity Testing in Patients with Pathological Germline Variants in Breast Cancer High-Susceptibility Genes <i>BReast CAncer 1</i> and <i>BReast CAncer 2</i>

Ex Vivo Chromosomal Radiosensitivity Testing in Patients with Pathological Germline Variants in Breast Cancer High-Susceptibility Genes <i>BReast CAncer 1</i> and <i>BReast CAncer 2</i>

Background: Individual radiosensitivity is an important factor in the occurrence of undesirable consequences of radiotherapy. The potential for increased radiosensitivity has been linked to highly penetrant heterozygous mutations in DNA repair genes such as <i>BRCA1</i> and <i>BRCA...

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Bibliographic Details
Main Authors: Tara Zuhair Kassem, Marius Wunderle, Lukas Kuhlmann, Matthias Ruebner, Hanna Huebner, Juliane Hoyer, André Reis, Peter A. Fasching, Matthias W. Beckmann, Carolin C. Hack, Rainer Fietkau, Luitpold Distel
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Current Issues in Molecular Biology
Subjects:
<i>BRCA1</i>
<i>BRCA2</i>
breast cancer
chromosomal radiosensitivity
FISH assay
radiation oncology
Online Access:https://www.mdpi.com/1467-3045/45/8/418

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https://www.mdpi.com/1467-3045/45/8/418

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