Targeting NETs using dual-active DNase1 variants

Targeting NETs using dual-active DNase1 variants

BackgroundNeutrophil Extracellular Traps (NETs) are key mediators of immunothrombotic mechanisms and defective clearance of NETs from the circulation underlies an array of thrombotic, inflammatory, infectious, and autoimmune diseases. Efficient NET degradation depends on the combined activity of two...

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Bibliographic Details
Main Authors: Hanna Englert, Josephine Göbel, Danika Khong, Maryam Omidi, Nina Wolska, Sandra Konrath, Maike Frye, Reiner K. Mailer, Manu Beerens, Julian C. Gerwers, Roger J. S. Preston, Jacob Odeberg, Lynn M. Butler, Coen Maas, Evi X. Stavrou, Tobias A. Fuchs, Thomas Renné
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
neutrophil extracellular traps (NETs)
NETosis
NET degradation
DNase1
DNase1-like 3
thromboinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1181761/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1181761/full

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