Overcoming Immunological Challenges Limiting Capsid-Mediated Gene Therapy With Machine Learning

Overcoming Immunological Challenges Limiting Capsid-Mediated Gene Therapy With Machine Learning

A key hurdle to making adeno-associated virus (AAV) capsid mediated gene therapy broadly beneficial to all patients is overcoming pre-existing and therapy-induced immune responses to these vectors. Recent advances in high-throughput DNA synthesis, multiplexing and sequencing technologies have accele...

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Bibliographic Details
Main Authors: Anna Z. Wec, Kathy S. Lin, Jamie C. Kwasnieski, Sam Sinai, Jeff Gerold, Eric D. Kelsic
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
gene therapy
protein engineering
immune evasion
machine learning
AAV capsid design
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.674021/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.674021/full

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