Amitozyn impairs chromosome segregation and induces apoptosis via mitotic checkpoint activation.

Amitozyn impairs chromosome segregation and induces apoptosis via mitotic checkpoint activation.

Amitozyn (Am) is a semi-synthetic drug produced by the alkylation of major celandine (Chelidonium majus L.) alkaloids with the organophosphorous compound N,N'N'-triethylenethiophosphoramide (ThioTEPA). We show here that the treatment of living cells with Am reversibly perturbs the microtub...

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Bibliographic Details
Main Authors: Bastien Hermant, Aldrian Gudrun, Anatoly I Potopalsky, Jadwiga Chroboczek, Sergey O Tcherniuk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3591406?pdf=render

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http://europepmc.org/articles/PMC3591406?pdf=render

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