Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting

Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting

Summary: Eliciting antibodies to surface-exposed viral glycoproteins can generate protective responses that control and prevent future infections. Targeting conserved sites may reduce the likelihood of viral escape and limit the spread of related viruses with pandemic potential. Here we leverage rat...

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Bibliographic Details
Main Authors: Blake M. Hauser, Maya Sangesland, Kerri J. St. Denis, Evan C. Lam, James Brett Case, Ian W. Windsor, Jared Feldman, Timothy M. Caradonna, Ty Kannegieter, Michael S. Diamond, Alejandro B. Balazs, Daniel Lingwood, Aaron G. Schmidt
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Cell Reports
Subjects:
immunogen design
glycan
immune focusing
SARS-CoV-2
coronavirus
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722003059

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http://www.sciencedirect.com/science/article/pii/S2211124722003059

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